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Sibutramine hydrochloride is a selective serotonin and noradrenaline re-uptake inhibitor. Obesity management is the main medical use of sibutramine. This is not a rapid acting drug. In other words it works rather slow and in a safe manner. This leads to a steady reduction in fat mass. Longer-term results can be maintained . This drug is most effective in conjunction with a low calorie diet and training program.